L'Isle-sur-la-Sorgue is a town and commune on the Sorgue river in southeastern France. Politically, the commune is in the arrondissement of Avignon within the département of Vaucluse and the région of Provence-Alpes-Côte d'Azur.
The small town is famous for its many antique shops and hosts antique markets most Sundays. It has many waterside cafés and restaurants, all within walking distance of each other. Its many attractive water wheels throughout the town are still in working order. Keith Floyd, the British TV chef and bon viveur, established a restaurant there during a lengthy sojourn in France.
L'Isle-sur-la-Sorgue is twinned with the towns of Penicuik in the UK, and Anagni in Italy.